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Literature summary for 3.4.21.20 extracted from

  • Wang, J.; Sjoeberg, S.; Tang, T.T.; Ooerni, K.; Wu, W.; Liu, C.; Secco, B.; Tia, V.; Sukhova, G.K.; Fernandes, C.; Lesner, A.; Kovanen, P.T.; Libby, P.; Cheng, X.; Shi, G.P.
    Cathepsin G activity lowers plasma LDL and reduces atherosclerosis (2014), Biochim. Biophys. Acta, 1842, 2174-2183.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.20

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cadherin + H2O Homo sapiens
-
 ?
-
 ?
cadherin + H2O Mus musculus
-
 ?
-
 ?
low-density lipoprotein + H2O Homo sapiens
-
 ?
-
 ?
low-density lipoprotein + H2O Mus musculus
-
 ?
-
 ?
additional information Homo sapiens the enzyme does not hydrolyze high-density lipoprotein ?
-
 ?
additional information Mus musculus the enzyme does not hydrolyze high-density lipoprotein ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P08311
-
-
Mus musculus P28293
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-
blood plasma
-
 Mus musculus
-
endothelial cell
-
 Homo sapiens
-
endothelial cell
-
 Mus musculus
-
macrophage
-
 Homo sapiens
-
macrophage
-
 Mus musculus
-
smooth muscle cell
-
 Homo sapiens
-
smooth muscle cell
-
 Mus musculus
-
T-lymphocyte
-
 Homo sapiens
-
T-lymphocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cadherin + H2O
-
 Homo sapiens ?
-
 ?
cadherin + H2O
-
 Mus musculus ?
-
 ?
low-density lipoprotein + H2O
-
 Homo sapiens ?
-
 ?
low-density lipoprotein + H2O
-
 Mus musculus ?
-
 ?
additional information the enzyme does not hydrolyze high-density lipoprotein Homo sapiens ?
-
 ?
additional information the enzyme does not hydrolyze high-density lipoprotein Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
CatG
-
 Homo sapiens
CatG
-
 Mus musculus

Expression

Organism Comment Expression
Homo sapiens patients with atherosclerosis have significantly reduced plasma enzyme levels down
Mus musculus patients with atherosclerosis have significantly reduced plasma enzyme levels down

General Information

General Information Comment Organism
malfunction the absence of cathepsin G reduces arterial wall elastin degradation and attenuates early atherosclerosis when mice consume a Western diet for 3 months Mus musculus
physiological function cathepsin G activity lowers plasma low-density lipoprotein and reduces atherosclerosis. The enzyme promotes early atherogenesis through its elastinolytic activity, but suppresses late progression of atherosclerosis by degrading low-density lipoprotein without affecting high-density lipoprotein or triglycerides Homo sapiens
physiological function cathepsin G activity lowers plasma low-density lipoprotein and reduces atherosclerosis. The enzyme promotes early atherogenesis through its elastinolytic activity, but suppresses late progression of atherosclerosis by degrading low-density lipoprotein without affecting high-density lipoprotein or triglycerides Mus musculus