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Literature summary for 3.4.21.20 extracted from

  • Korkmaz, B.; Jegot, G.; Lau, L.C.; Thorpe, M.; Pitois, E.; Juliano, L.; Walls, A.F.; Hellman, L.; Gauthier, F.
    Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates (2011), FEBS J., 278, 2635-2646.
    View publication on PubMed
Search for more literature for 3.4.21.20

Protein Variants

Protein Variants Comment Organism
A226E the substitution at the bottom of the cathepsin G S1 pocket allows cathepsin G to accommodate a Lys residue at P1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-succinyl-L-Ala-L-Ala-L-Pro-L-Phe-chloromethylketone irreversible inhibitor Homo sapiens
N-succinyl-L-Val-L-Pro-L-Phe-(OPh)2 irreversible inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P08311
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Abz-GIAPFCDLMPEQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-GIATFCDLMPEQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-GIATFCMLMPEQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-GIATFCPLMPEQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-GIATFCRLMPEQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-GIATFDMLMPEQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-GIATFRMLMPEQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-GIATFSMLMPEQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-GIATFWMLMPEQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-GIEPFSDPMPEQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-GIEPKSDPMPEQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-GIEPKSDPMPEQ-N-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-TPFSALQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-TPKSALQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-TPWSALQ-YNO2 + H2O
-
 Homo sapiens ?
-
 ?

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
8.1
-
 Abz-TPKSALQ-EDDnp at 37°C in 50mM HEPES buffer (pH 7.4), 100 mM NaCl Homo sapiens
68
-
 Abz-GIATFCRLMPEQ-EDDnp at 37°C in 50mM HEPES buffer (pH 7.4), 100 mM NaCl Homo sapiens
69
-
 Abz-GIATFWMLMPEQ-EDDnp at 37°C in 50mM HEPES buffer (pH 7.4), 100 mM NaCl Homo sapiens
69
-
 Abz-TPWSALQ-YNO2 at 37°C in 50mM HEPES buffer (pH 7.4), 100 mM NaCl Homo sapiens
153.8
-
 Abz-TPFSALQ-EDDnp at 37°C in 50mM HEPES buffer (pH 7.4), 100 mM NaCl Homo sapiens
162
-
 Abz-GIATFRMLMPEQ-EDDnp at 37°C in 50mM HEPES buffer (pH 7.4), 100 mM NaCl Homo sapiens
175
-
 Abz-GIATFDMLMPEQ-EDDnp at 37°C in 50mM HEPES buffer (pH 7.4), 100 mM NaCl Homo sapiens
190
-
 Abz-GIEPKSDPMPEQ-EDDnp at 37°C in 50mM HEPES buffer (pH 7.4), 100 mM NaCl Homo sapiens
217
-
 Abz-GIATFSMLMPEQ-EDDnp at 37°C in 50mM HEPES buffer (pH 7.4), 100 mM NaCl Homo sapiens
263
-
 Abz-GIATFCMLMPEQ-EDDnp at 37°C in 50mM HEPES buffer (pH 7.4), 100 mM NaCl Homo sapiens
560
-
 Abz-GIATFCPLMPEQ-EDDnp at 37°C in 50mM HEPES buffer (pH 7.4), 100 mM NaCl Homo sapiens
817
-
 Abz-GIATFCDLMPEQ-EDDnp at 37°C in 50mM HEPES buffer (pH 7.4), 100 mM NaCl Homo sapiens
1700
-
 Abz-GIEPFSDPMPEQ-EDDnp at 37°C in 50mM HEPES buffer (pH 7.4), 100 mM NaCl Homo sapiens
2054
-
 Abz-GIAPFCDLMPEQ-EDDnp at 37°C in 50mM HEPES buffer (pH 7.4), 100 mM NaCl Homo sapiens