Literature summary for 3.4.21.20 extracted from

Tausch, L.; Henkel, A.; Siemoneit, U.; Poeckel, D.; Kather, N.; Franke, L.; Hofmann, B.; Schneider, G.; Angioni, C.; Geisslinger, G.; Skarke, C.; Holtmeier, W.; Beckhaus, T.; Karas, M.; Jauch, J.; Werz, O.
Identification of human cathepsin G as a functional target of boswellic acids from the anti-inflammatory remedy frankincense (2009), J. Immunol., 183, 3433-3442.

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Inhibitors

Inhibitors	Comment	Organism	Structure
11-oxo-beta-boswellic acid	0.01 mM, 30% cathepsin G activity compared to control	Homo sapiens
3-O-acetyl-11-oxo-beta-boswellic acid	0.01 mM, 15% cathepsin G activity compared to control	Homo sapiens
3-O-acetyl-beta-boswellic acid	0.01 mM, 5% cathepsin G activity compared to control	Homo sapiens
beta-boswellic acid	0.01 mM, 30% cathepsin G activity compared to control	Homo sapiens
glut-11-oxo-beta-boswellic acid	0.01 mM 20% cathepsin G activity compared to control	Homo sapiens
ursolic acid	0.01 mM, 80% cathepsin G activity compared to control	Homo sapiens
[2-(3-[methyl[1-(2-naphthoyl)piperidin-4-yl]amino]carbonyl]-2-naphthyl)-1-(1-naphthyl)-2-oxoethyl]phosphonic acid	0.0005 mM, 10% cathepsin G activity compared to control	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lysosome	-	Homo sapiens	5764	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
26000	-	MALDI-TOF	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P08311	-	-

Purification (Commentary)

Purification (Comment)	Organism
ammonium sulfate precipitation, elastin-Sepharose affinity chromatography, ion-exchange chromatography	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
neutrophil	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide + H2O	assay at pH 7.4, 25°C	Homo sapiens	N-succinyl-Ala-Ala-Pro-Phe + p-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
cat G	-	Homo sapiens
cathepsin G	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
25	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)