Literature summary for 3.4.21.20 extracted from

Dabek, M.; Ferrier, L.; Roka, R.; Gecse, K.; Annahazi, A.; Moreau, J.; Escourrou, J.; Cartier, C.; Chaumaz, G.; Leveque, M.; Ait-Belgnaoui, A.; Wittmann, T.; Theodorou, V.; Bueno, L.
Luminal cathepsin g and protease-activated receptor 4: a duet involved in alterations of the colonic epithelial barrier in ulcerative colitis (2009), Am. J. Pathol., 175, 207-214.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride	-	Homo sapiens
specific Cat-G inhibitor	1 microM, decrease of enzyme activity by 43%	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
39000	-	Western blot	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colon	-	Homo sapiens	-
feces	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	15% cathepsin G acitivity among total proteolytic activity of fecal supernatants, in patients with ulcerative colitits	Homo sapiens
additional information	-	7% cathepsin G acitivity among total proteolytic activity of fecal supernatants, in healthy patients	Homo sapiens
2.02	-	healthy subjects	Homo sapiens
16.14	-	patients with ulcerative colitis and specific Cat-G inhibitor	Homo sapiens
28.34	-	patients with ulcerative colitis	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide + H2O	assay at 37°C	Homo sapiens	N-succinyl-Ala-Ala-Pro-Phe + p-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
Cat-G	-	Homo sapiens
cathepsin G	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	higher expression of Cat-G in biopsies from patients with ulcerative colitis	up

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Release 2023.1 (January 2023)