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Literature summary for 3.4.21.20 extracted from

  • Wilson, T.J.; Nannuru, K.C.; Singh, R.K.
    Cathepsin G recruits osteoclast precursors via proteolytic activation of protease-activated receptor-1 (2009), Cancer Res., 69, 3188-3195.
    View publication on PubMed
Search for more literature for 3.4.21.20

Inhibitors

Inhibitors Comment Organism Structure
N-tosyl-L-phenylalanine chloromethyl ketone TPCK, inhibitor of the proteolytic activity of cathepsin G, effectively eliminated cathepsin G-induced chemotaxis of monocytes Homo sapiens
N-tosyl-L-phenylalanine chloromethyl ketone TPCK, inhibitor of the proteolytic activity of cathepsin G, effectively eliminated cathepsin G-induced chemotaxis of monocytes Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus cathepsin G shows a concentration-dependent induction of monocyte chemotaxis. At the highest concentrations, it induced chemotaxis similar to MCP-1, a known monocyte chemoattractant ?
-
 ?
additional information Homo sapiens cathepsin G shows a concentration-dependent induction of monocyte chemotaxis. At the highest concentrations, it induced chemotaxis similar to MCP-1, a known monocyte chemoattractant ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 female BALB/c mice
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
Cl-66 cell mammary tumor cell Mus musculus
-
Cl-66M2 cell breast adenocarcinoma cell line Mus musculus
-
PBMC cell peripheral blood mononuclear cell Homo sapiens
-
RAW-264.7 cell monocyte/macrophage cell line Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cathepsin G shows a concentration-dependent induction of monocyte chemotaxis. At the highest concentrations, it induced chemotaxis similar to MCP-1, a known monocyte chemoattractant Mus musculus ?
-
 ?
additional information cathepsin G shows a concentration-dependent induction of monocyte chemotaxis. At the highest concentrations, it induced chemotaxis similar to MCP-1, a known monocyte chemoattractant Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
cathepsin G
-
 Mus musculus
cathepsin G
-
 Homo sapiens