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Literature summary for 3.4.21.20 extracted from

  • Campbell, E.J.; Owen, C.A.
    The sulfate groups of chondroitin sulfate- and heparan sulfate-containing proteoglycans in neutrophil plasma membranes are novel binding sites for human leukocyte elastase and cathepsin G (2007), J. Biol. Chem., 282, 14645-14654.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface expression at high levels on the surface of activated human neutrophils in catalytically active but inhibitor-resistant form Homo sapiens 9986
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plasma membrane mechanism by which the enzyme binds to activated human neutrophil plasma membranes, a functional active site is not required for binding, overview, inhibition of binding by 1. trypsin, chondroitinase ABC, and heparitinases, but not other glycanases, and by 2. purified chondroitin sulfates, heparan sulfate, and other sulfated molecules, but not by non-sulfated glycans, binding kinetics, overview Homo sapiens 5886
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
neutrophil expression at high levels on the surface of activated human neutrophils in catalytically active but inhibitor-resistant form Homo sapiens
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sputum purulent Homo sapiens
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