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Literature summary for 3.4.21.20 extracted from

  • Burster, T.; Beck, A.; Poeschel, S.; Oren, A.; Baechle, D.; Reich, M.; Roetzschke, O.; Falk, K.; Boehm, B.O.; Youssef, S.; Kalbacher, H.; Overkleeft, H.; Tolosa, E.; Driessen, C.
    Interferon-gamma regulates cathepsin G activity in microglia-derived lysosomes and controls the proteolytic processing of myelin basic protein in vitro (2007), Immunology, 121, 82-93.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.20

Protein Variants

Protein Variants Comment Organism
additional information when microglia are treated with interferon-gamma to mimic a T helper type 1-biased cytokine milieu in multiple sclerosis, CatG is drastically down-regulated resulting in significantly increased stability of myelin basic protein and a selective lack of CatG-derived proteolytic fragments Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information when microglia are treated with interferon-gamma to mimic a T helper type 1-biased cytokine milieu in multiple sclerosis, CatG is drastically down-regulated resulting in significantly increased stability of myelin basic protein and a selective lack of CatG-derived proteolytic fragments, inhibition of serine proteases eliminates differences in lysosomal MBP-processing between resting and IFN-gamma-stimulated microglia Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome derived from primary murine microglia Mus musculus 5764
-
lysosome microglia-derived Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
myelin basic protein + H2O Homo sapiens the serine protease cathepsin G dominates the proteolytic processing of the multiple sclerosis-associated autoantigen myelin basic protein in lysosomes from primary B cells and dendritic cells, overview myelin basic protein peptide fragments
-
 ?
myelin basic protein + H2O Mus musculus when microglia are treated with interferon-gamma to mimic a T helper type 1-biased cytokine milieu in multiple sclerosis, CatG is drastically down-regulated resulting in significantly increased stability of myelin basic protein and a selective lack of CatG-derived proteolytic fragments myelin basic protein peptide fragments
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-cell
-
 Homo sapiens
-
dendritic cell
-
 Homo sapiens
-
microglia
-
 Mus musculus
-
microglia
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
myelin basic protein + H2O
-
 Homo sapiens myelin basic protein peptide fragments
-
 ?
myelin basic protein + H2O the serine protease cathepsin G dominates the proteolytic processing of the multiple sclerosis-associated autoantigen myelin basic protein in lysosomes from primary B cells and dendritic cells, overview Homo sapiens myelin basic protein peptide fragments
-
 ?
myelin basic protein + H2O when microglia are treated with interferon-gamma to mimic a T helper type 1-biased cytokine milieu in multiple sclerosis, CatG is drastically down-regulated resulting in significantly increased stability of myelin basic protein and a selective lack of CatG-derived proteolytic fragments Mus musculus myelin basic protein peptide fragments
-
 ?
myelin basic protein + H2O substrate is recombinant purified human myelin basic protein, differential processing patterns, overview Mus musculus myelin basic protein peptide fragments determination of proteolysis products ?
succinyl-alanyl-alanyl-prolyl-phenylalanyl-aminomethyl-coumarin + H2O a fluorogenic substrate Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
CatG
-
 Mus musculus
CatG
-
 Homo sapiens