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Literature summary for 3.4.21.20 extracted from

  • Bonnefoy, A.; Legrand, C.
    Proteolysis of subendothelial adhesive glycoproteins (fibronectin, thrombospondin, and von Willebrand factor) by plasmin, leukocyte cathepsin G, and elastase (2000), Thromb. Res., 98, 323-332.
    View publication on PubMed
Search for more literature for 3.4.21.20

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibronectin + H2O Homo sapiens proteolysis causes no change in endothelial cell morphology, involved in release of extracellular matrix components during inflammation peptide fragments
-
 ?
thrombospondin + H2O Homo sapiens proteolysis causes no change in endothelial cell morphology, involved in release of extracellular matrix components during inflammation peptide fragments
-
 ?
von Willebrand factor + H2O Homo sapiens proteolysis causes no change in endothelial cell morphology, involved in release of extracellular matrix components during inflammation peptide fragments
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation from leukocytes Homo sapiens
-
leukocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
148
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibronectin + H2O 220 kDa substrate in extracellular matrix of human umbilical vein endothelial cells and platelets Homo sapiens peptide fragments 162 kDa, 122 kDa, and 92 kDa ?
fibronectin + H2O proteolysis causes no change in endothelial cell morphology, involved in release of extracellular matrix components during inflammation Homo sapiens peptide fragments
-
 ?
thrombospondin + H2O preferred substrate, 180 kDa substrate in extracellular matrix of human umbilical vein endothelial cells and platelets Homo sapiens peptide fragments 155 kDa and 25 kDa ?
thrombospondin + H2O proteolysis causes no change in endothelial cell morphology, involved in release of extracellular matrix components during inflammation Homo sapiens peptide fragments
-
 ?
von Willebrand factor + H2O 280 kDa substrate in extracellular matrix of human umbilical vein endothelial cells and platelets Homo sapiens peptide fragments 260-177 kDa and 177-136 kDa ?
von Willebrand factor + H2O proteolysis causes no change in endothelial cell morphology, involved in release of extracellular matrix components during inflammation Homo sapiens peptide fragments
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens