Literature summary for 3.4.21.12 extracted from

Haddad, K.C.; Sudmeier, J.L.; Bachovchin, D.A.; Bachovchin, W.W.
alpha-Lytic protease can exist in two separately stable conformations with different His57 mobilities and catalytic activities (2005), Proc. Natl. Acad. Sci. USA, 102, 1006-1011.

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General Stability

General Stability	Organism
alpha-lytic protease can exist in two separately stable conformations with different His57 mobilities and catalytic activities	Lysobacter enzymogenes
lyophilization induces a structural change in the enzyme that is not reversed by redissolution in water. The structural change reduces the mobility of the active-site histidine residue and the catalytic activity of the enzyme. The application of mild pressure to solutions of the altered enzyme reverses the lyophilization-induced structural change and restores the mobility of the histidine residue and the enzyme's catalytic activity	Lysobacter enzymogenes

Organism

alpha-lytic protease can exist in two separately stable conformations with different His57 mobilities and catalytic activities

Lysobacter enzymogenes

lyophilization induces a structural change in the enzyme that is not reversed by redissolution in water. The structural change reduces the mobility of the active-site histidine residue and the catalytic activity of the enzyme. The application of mild pressure to solutions of the altered enzyme reverses the lyophilization-induced structural change and restores the mobility of the histidine residue and the enzyme's catalytic activity

Lysobacter enzymogenes

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	lyophilization induces a structural change in the enzyme that is not reversed by redissolution in water. The structural change reduces the mobility of the active-site histidine residue and the catalytic activity of the enzyme. The application of mild pressure to solutions of the altered enzyme reverses the lyophilization-induced structural change and restores the mobility of the histidine residue and the enzyme's catalytic activity	Lysobacter enzymogenes

Organism

Organism	UniProt	Comment	Textmining
Lysobacter enzymogenes	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-Ala-Pro-Ala-4-nitroanilide + H2O	-	Lysobacter enzymogenes	?	-	?

Synonyms

Synonyms	Comment	Organism
alpha-lytic protease	-	Lysobacter enzymogenes