Cloned (Comment) | Organism |
---|---|
expression in Pichia pastoris | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
extracellular | enzyme is also secreted into biological fluids | Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
30000 | - |
secreted enzyme, gel filtration | Homo sapiens |
50000 | - |
x * 50000, recombinant glycosylated enzyme, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
polypeptide + H2O | Homo sapiens | - |
peptides | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | enzyme is highly glycosylated | Homo sapiens |
Purification (Comment) | Organism |
---|---|
recombinant enzyme from Pichia pastoris | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
Hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg-/- pair in the N-terminus, to yield mature renin | enzyme is a serine protease | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amniotic fluid | - |
Homo sapiens | - |
ascites fluid | from women with advanced ovarian carcinoma | Homo sapiens | - |
breast | - |
Homo sapiens | - |
cerebrospinal fluid | traces | Homo sapiens | - |
esophagus | highest activity in esophagus and tonsil | Homo sapiens | - |
kidney | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
milk | - |
Homo sapiens | - |
additional information | fetal tissue pattern is similar to the adult one | Homo sapiens | - |
ovarian follicle | - |
Homo sapiens | - |
prostate | - |
Homo sapiens | - |
salivary gland | - |
Homo sapiens | - |
seminal plasma | - |
Homo sapiens | - |
skin | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
thyroid gland | - |
Homo sapiens | - |
tonsil | highest activity in esophagus and tonsil | Homo sapiens | - |
trachea | - |
Homo sapiens | - |
ureter | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
FSR-amido-4-methylcoumarin + H2O | fluorogenic trypsin-like peptide substrate | Homo sapiens | FSR + 7-amino-4-methylcoumarin | - |
? | |
polypeptide + H2O | - |
Homo sapiens | peptides | - |
? | |
VPR-amido-4-methylcoumarin + H2O | fluorogenic trypsin-like peptide substrate | Homo sapiens | VPR + 7-amino-4-methylcoumarin | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 50000, recombinant glycosylated enzyme, SDS-PAGE | Homo sapiens |
? | x * 25000-28000, recombinant deglycosylated enzyme, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
K13 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |