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Literature summary for 3.4.21.119 extracted from

  • Kikkawa, Y.; Yamanaka, N.; Tada, J.; Kanamori, N.; Tsumura, K.; Hosoi, K.
    Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22) (1998), Biochim. Biophys. Acta, 1382, 55-64.
    View publication on PubMed
Search for more literature for 3.4.21.119

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 8-10 weeks old male ICR mice
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Reaction

Reaction Comment Organism Reaction ID
Hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg-/- pair in the N-terminus, to yield mature renin preference for Xaa-Arg-Arg- motif Mus musculus
a

Source Tissue

Source Tissue Comment Organism Textmining
submandibular gland
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0011
-
 purified enzyme, substrate benzyloxycarbonyl-Gln-Arg-Arg-4-methyl-coumaryl-7-amide Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Arg-Val-Arg-Arg-4-methyl-coumaryl-7-amide + H2O low activity Mus musculus benzyloxycarbonyl-Arg-Val-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?
benzyloxycarbonyl-Gln-Arg-Arg-4-methyl-coumaryl-7-amide + H2O best substrate Mus musculus benzyloxycarbonyl-Gln-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?
benzyloxycarbonyl-Glu-Lys-Lys-4-methyl-coumaryl-7-amide + H2O low activity Mus musculus benzyloxycarbonyl-Glu-Lys-Lys + 7-amino-4-methylcoumarin
-
 ?
benzyloxycarbonyl-Leu-Lys-Arg-4-methyl-coumaryl-7-amide + H2O
-
 Mus musculus benzyloxycarbonyl-Leu-Lys-Arg + 7-amino-4-methylcoumarin
-
 ?
Prorenin + H2O cleavage site at paired basic amino acid residues Mus musculus Renin + ?
-
 ?
Prorenin + H2O recombinant murine prorenin 2 Mus musculus Renin + ?
-
 ?
pyroglutamyl-Arg-Tyr-Lys-Arg-4-methyl-coumaryl-7-amide + H2O
-
 Mus musculus pyroglutamyl-Arg-Tyr-Lys-Arg + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
prorenin-converting enzyme
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Mus musculus