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Literature summary for 3.4.21.117 extracted from

  • Morizane, S.; Yamasaki, K.; Kabigting, F.D.; Gallo, R.L.
    Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D3, and retinoic acid (2010), J. Invest. Dermatol., 130, 1297-1306.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.117

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
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 Homo sapiens
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keratinocyte KLK7, KLK5, and cathelicidin colocalizes in keratinocytes lamellar granules stimulated with 1,25(OH)2VD3 Homo sapiens
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skin
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
kallikrein 7
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 Homo sapiens
KLK7
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens increased extracellular calcium-induced KLK7 mRNA expression and protein release in epidermal keratinocyte. Increased protease activity and differential processing of cathelicidin accompanies increased KLK expression. 1,25(OH)2VD3 increases KLK expression independently of differentiation in keratinocytes up

General Information

General Information Comment Organism
physiological function the serine proteases kallikrein 5 and kallikrein 7 control enzymatic processing of cathelicidin precursor in the skin and regulate the eventual function of the final forms of these peptides Homo sapiens