Cloned (Comment) | Organism |
---|---|
stable overexpression of KLK7-253 in SKOV-3 cells, leading to formation of multicellular aggregates, MCAs, that promote cell survival and chemoresistance, with involvement of KLK7 and integrin-regulated cell adhesion. KLK7-253 cells form MCAs invade into mesothelial cell monolayers | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
two different KLK7 transcripts, KLK7-253 and KLK7-181 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ovary cancer cell | KLK7 is upregulated in epithelial ovarian carcinoma, expression of two different KLK7 transcripts, KLK7-253 and KLK7-181, simultaneously | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
kallikrein-related peptidase 7 | - |
Homo sapiens |
KLK7 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | KLK7 is upregulated in epithelial ovarian carcinoma with high levels correlated with poor prognosis. Mechanism for association of high KLK7 levels with chemoresistance and poor prognosis for serous EOC patients by promotion of peritoneal dissemination and reinvasion via increased MCA and alpha5beta1 integrin-dependent cell adhesion | Homo sapiens |