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Literature summary for 3.4.21.117 extracted from

  • Ohler, A.; Debela, M.; Wagner, S.; Magdolen, V.; Becker-Pauly, C.
    Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation (2010), Biol. Chem., 391, 455-460.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information KLK7 is activated by proteolytic cleavage through meprin alpha and beta, and through trypsin, overview. Cleavage by meprins enhances activation of LKL7 through trypsin Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification proKLK7 is processed and activated by meprin metalloproteases alpha and beta, which need to activated themselves by specifically by KLK4, KLK5, and KLK8, overview. Meprins cleave within the N-terminal region of proKLK7. This triggering leads to an accelerated activation of KLK7 (approximately 150%) in the presence of trypsin, overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
 Homo sapiens
-
keratinocyte
-
 Homo sapiens
-
skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Suc-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Suc-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
KLK7
-
 Homo sapiens