Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | KLK7 is activated by proteolytic cleavage through meprin alpha and beta, and through trypsin, overview. Cleavage by meprins enhances activation of LKL7 through trypsin | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | proKLK7 is processed and activated by meprin metalloproteases alpha and beta, which need to activated themselves by specifically by KLK4, KLK5, and KLK8, overview. Meprins cleave within the N-terminal region of proKLK7. This triggering leads to an accelerated activation of KLK7 (approximately 150%) in the presence of trypsin, overview | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | - |
Homo sapiens | - |
keratinocyte | - |
Homo sapiens | - |
skin | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Suc-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Suc-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
KLK7 | - |
Homo sapiens |