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Literature summary for 3.4.21.117 extracted from

  • Ramani, V.C.; Hennings, L.; Haun, R.S.
    Desmoglein 2 is a substrate of kallikrein 7 in pancreatic cancer (2008), BMC Cancer, 8, 373.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.117

Application

Application Comment Organism
molecular biology kallikrein 7 may play a critical role in the invasion of cancer cells in which it is aberrantly expressed by degrading important cell adhesive molecules like desmogleins and E-cadherin Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
chymostatin proteolysis of both the desmosomal proteins by kallikrein 7 is effectively inhibited in the presence of chymostatin Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreatic cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
desmoglein 1 + H2O kallikrein 7 cleaves both recombinant desmoglein 1 and desmoglein 2 in vitro Homo sapiens ?
-
 ?
desmoglein 2 + H2O kallikrein 7 cleaves both recombinant desmoglein 1 and desmoglein 2 in vitro. Ectopic expression of kallikrein 7 in BxPC-3 pancreatic cancer cells which express desoglein 2 but not desmoglein 1 or kallikrein 7 confirms the cleavage of desmoglein 2 in vivo Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
kallikrein 7
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens