Any feedback?
Literature summary for 3.4.21.117 extracted from
- Kallikrein 7 enhances pancreatic cancer cell invasion by shedding E-cadherin (2007), Cancer, 109, 1811-1820.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene KLK7, expression profiling in BxPC-3 cells from pancreatic adenocarcinomas | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| chymostatin | - |
Homo sapiens |  |
| additional information | phosphoramidon inhibits thermolysin and thus activation of pro-kallikrein 7 | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| E-cadherin + H2O | Homo sapiens | kallikrein 7 degrades extracellular matrix proteins, and enhances pancreatic cancer cell invasion by shedding E-cadherin, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
gene KLK7 | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | activation of recombinant pro-kallikrein 7 by thermolysin, inhibited by phosphoramidon | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| BxPC-3 cell | - |
Homo sapiens | - |
| commercial preparation | recombinant pro-kallikrein 7 | Homo sapiens | - |
| PANC-1 cell | - |
Homo sapiens | - |
| pancreatic cancer cell | PCR expression profile of serine proteases from both healthy and malignant pancreatic tissues | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
cell aggregation assay using Panc-1 cells | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| E-cadherin + H2O | kallikrein 7 degrades extracellular matrix proteins, and enhances pancreatic cancer cell invasion by shedding E-cadherin, overview | Homo sapiens | ? | - |
? | |
| E-cadherin + H2O | epithelial cell adhesion molecule | Homo sapiens | ? | - |
? | |
| Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 + H2O | a fluorogenic peptide substrate | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| kallikrein 7 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8.5 | assay at | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
