Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.117 extracted from

  • Deraison, C.; Bonnart, C.; Lopez, F.; Besson, C.; Robinson, R.; Jayakumar, A.; Wagberg, F.; Brattsand, M.; Hachem, J.P.; Leonardsson, G.; Hovnanian, A.
    LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction (2007), Mol. Biol. Cell, 18, 3607-3619.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
LEKTI i.e. lympho-epithelial Kazaltype-related inhibitor, a 15-domain serine proteinase inhibitor Homo sapiens
LEKTI fragments i.e. lympho-epithelial Kazaltype-related inhibitor fragments, furin-derived and secreted in cultured keratinocytes and in the epidermis, specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
gene KLK7
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
Homo sapiens
-
keratinocyte primary Homo sapiens
-
stratum corneum
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Arg-Pro-Tyr-4-nitroanilide + H2O
-
Homo sapiens ?
-
?
MeO-succinly-Arg-Pro-Tyr-4-nitroanilide + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
KLK7
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics with LEKTi fragments, overview Homo sapiens