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Literature summary for 3.4.21.117 extracted from

  • Skytt, A.; Stromqvist, M.; Egelrud, T.
    Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme (1995), Biochem. Biophys. Res. Commun., 211, 586-589.
    View publication on PubMed
Search for more literature for 3.4.21.117

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
polypeptide + H2O Homo sapiens involved in desquamation in plantar stratum corneum peptides
-
 ?
polypeptide + H2O Homo sapiens catalyzes the degradation of intercellular cohesive structures in the cornified layer of the skin in the continous sheeding of the cells from the skin surface peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
cleavage of proteins with aromatic side chains in the P1 position specific for amino acid residues with aromatic side chains in the P1 position Homo sapiens
a
cleavage of proteins with aromatic side chains in the P1 position enzyme is a chymotrypsin-like serine protease Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
epidermis enzyme expression Homo sapiens
-
keratinocyte enzyme expression Homo sapiens
-
skin
-
 Homo sapiens
-
stratum corneum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information substrate specificity Homo sapiens ?
-
 ?
oxidized bovine insulin B chain + H2O recombinant enzyme Homo sapiens peptides + (Tyr)26 product identification, cleavage sites are: Leu6-cysteic acid7, Tyr16-Leu17, Phe25-Tyr26, Tyr26-Tr27 ?
polypeptide + H2O
-
 Homo sapiens peptides
-
 ?
polypeptide + H2O involved in desquamation in plantar stratum corneum Homo sapiens peptides
-
 ?
polypeptide + H2O catalyzes the degradation of intercellular cohesive structures in the cornified layer of the skin in the continous sheeding of the cells from the skin surface Homo sapiens peptides
-
 ?

Synonyms

Synonyms Comment Organism
SCCE
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Homo sapiens