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Literature summary for 3.4.21.117 extracted from

  • Hansson, L.; Stromqvist, M.; Backman, A.; Wallbrandt, P.; Carlstein, A.; Egelrud, T.
    Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase (1994), J. Biol. Chem., 269, 19420-19426.
    View publication on PubMed
Search for more literature for 3.4.21.117

Cloned(Commentary)

Cloned (Comment) Organism
cloning from keratinocyte library, DNA and RNA sequence determination and analysis, expression of the enzyme in its proform in murine C127 cells, enzyme activation by trypsin Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
polypeptide + H2O Homo sapiens
-
 peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P49862 gene KLK7, RNA sequence
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein recombinant and native enzyme Homo sapiens
glycoprotein enzyme contains 1 potential N-glycosylation site Homo sapiens
proteolytic modification recombinant enzyme proform is activated by digestion with trypsin Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
recombinant and native enzyme Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
cleavage of proteins with aromatic side chains in the P1 position enzyme is a chymotrypsin-like serine protease Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
epidermis enzyme expression Homo sapiens
-
keratinocyte enzyme expression Homo sapiens
-
additional information enzyme expression in restricted to skin Homo sapiens
-
skin
-
 Homo sapiens
-
stratum corneum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information recombinant enzyme proform is activated by digestion with trypsin Homo sapiens ?
-
 ?
polypeptide + H2O
-
 Homo sapiens peptides
-
 ?

Synonyms

Synonyms Comment Organism
SCCE
-
 Homo sapiens