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Literature summary for 3.4.21.117 extracted from
- Purification and preliminary characterization of stratum corneum chymotryptic enzyme: a proteinase that may be involved in desquamation (1993), J. Invest. Dermatol., 101, 200-204.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 25000 | - |
x * 25000, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| polypeptide + H2O | Homo sapiens | involved in desquamation in plantar stratum corneum | peptides | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| cleavage of proteins with aromatic side chains in the P1 position | enzyme is a chymotrypsin-like serine protease | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| corneocyte | plantar | Homo sapiens | - |
| skin | - |
Homo sapiens | - |
| stratum corneum | hyperplastic | Homo sapiens | - |
| stratum corneum | plantar | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Ile-Pro-Arg-4-nitroanilide + H2O | chromogenic substrate | Homo sapiens | D-Ile-Pro-Arg + 4-nitroaniline | - |
? | |
| D-Ile-Pro-Arg-4-nitroanilide + H2O | i.e. S2288 | Homo sapiens | D-Ile-Pro-Arg + 4-nitroaniline | - |
? | |
| methoxy-succinyl-Arg-Pro-Tyr-4-nitroanilide + H2O | best substrate | Homo sapiens | methoxy-succinyl-Arg-Pro-Tyr + 4-nitroaniline | - |
? | |
| methoxy-succinyl-Arg-Pro-Tyr-4-nitroanilide + H2O | chromogenic substrate | Homo sapiens | methoxy-succinyl-Arg-Pro-Tyr + 4-nitroaniline | - |
? | |
| methoxy-succinyl-Arg-Pro-Tyr-4-nitroanilide + H2O | i.e. S2586 | Homo sapiens | methoxy-succinyl-Arg-Pro-Tyr + 4-nitroaniline | - |
? | |
| polypeptide + H2O | - |
Homo sapiens | peptides | - |
? | |
| polypeptide + H2O | involved in desquamation in plantar stratum corneum | Homo sapiens | peptides | - |
? | |
| succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O | chromogenic substrate | Homo sapiens | succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 25000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SCCE | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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