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Literature summary for 3.4.21.117 extracted from
- The new human tissue kallikrein gene family: structure, function, and association to disease (2001), Endocr. Rev., 22, 184-204.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | estrogen and glucocorticoids cause up-regulation of gene expression | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene KLK7, genetic organization and structure of the kallikrein gene family, clustered on chromosome 19q13.3-q13.4 | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| polypeptide + H2O | Homo sapiens | involved in pathological keratinization, psoriasis, and ovarian cancer | peptides | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P49862 | - |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| cleavage of proteins with aromatic side chains in the P1 position | substrate binding pocket contains an Asn residue | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast | - |
Homo sapiens | - |
| BT-474 cell | breast carcinoma cell line, enzyme is upregulated by estrogens and slightly by glucocorticoids | Homo sapiens | - |
| central nervous system | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| ovarian carcinoma cell | overexpression of the enzyme | Homo sapiens | - |
| ovary | - |
Homo sapiens | - |
| placenta | low content | Homo sapiens | - |
| salivary gland | low content | Homo sapiens | - |
| skin | - |
Homo sapiens | - |
| testis | low content | Homo sapiens | - |
| thymus | low content | Homo sapiens | - |
| thyroid gland | low content | Homo sapiens | - |
| trachea | low content | Homo sapiens | - |
| uterus | low content | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| polypeptide + H2O | - |
Homo sapiens | peptides | - |
? | |
| polypeptide + H2O | involved in pathological keratinization, psoriasis, and ovarian cancer | Homo sapiens | peptides | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| K7 | - |
Homo sapiens |
| SCCE | - |
Homo sapiens |
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