Cloned (Comment) | Organism |
---|---|
- |
Bacillus subtilis |
Protein Variants | Comment | Organism |
---|---|---|
S378A | mutant with blocked self-cleavage | Bacillus subtilis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
42000 | - |
three predominant species of approximately 45000 Da, 43000 Da and 42000 Da after processing | Bacillus subtilis |
43000 | - |
three predominant species of approximately 45000 Da, 43000 Da and 42000 Da after processing | Bacillus subtilis |
45000 | - |
three predominant species of approximately 45000 Da, 43000 Da and 42000 Da after processing | Bacillus subtilis |
52000 | - |
S378A mutant, unprocessed proprotein | Bacillus subtilis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-sigmaK | Bacillus subtilis | enzyme is essential for intercompartmental signalling in the sigmaK-checkpoint, activates poteolytic processing of pro-sigmaK to its mature and active form sigmaK, function in formation of heat-resistant spores | sigmaK + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus subtilis | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | enzyme is able to self-cleave in trans into at least three discrete products, zymogen is subject to two levels of proteolysis: autoproteolysis generating intermediate products of 42000 Da, 43000 Da and 45000 Da, at least one of which is proposed to be the active form, followed by processing by one or more enzymes to smaller species of 42000 Da and 40000 Da | Bacillus subtilis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | self-cleavage occurs at three different sites: Val52 and Asn53, Ala62 and Phe63, Val74 and Thr75 | Bacillus subtilis | ? | - |
? | |
pro-sigmaK | - |
Bacillus subtilis | sigmaK + ? | - |
? | |
pro-sigmaK | enzyme is essential for intercompartmental signalling in the sigmaK-checkpoint, activates poteolytic processing of pro-sigmaK to its mature and active form sigmaK, function in formation of heat-resistant spores | Bacillus subtilis | sigmaK + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
S55.001 | Merops ID | Bacillus subtilis |