Literature summary for 3.4.21.113 extracted from

Riedel, C.; Lamp, B.; Heimann, M.; Koenig, M.; Blome, S.; Moennig, V.; Schuettler, C.; Thiel, H.J.; Ruemenapf, T.
The core protein of classical Swine Fever virus is dispensable for virus propagation in vitro (2012), PLoS Pathog., 8, e1002598.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Classical swine fever virus	pestiviral NS3 is a multifunctional molecule possessing protease, NTPase, and helicase activity	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Classical swine fever virus	P19712	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	pestiviral NS3 is a multifunctional molecule possessing protease, NTPase, and helicase activity	Classical swine fever virus	?	-	?

Synonyms

Synonyms	Comment	Organism
nonstructural protein 3	-	Classical swine fever virus
NS3	-	Classical swine fever virus

General Information

General Information	Comment	Organism
evolution	the enzyme is well conserved among the Flaviviridae	Classical swine fever virus
physiological function	nonstructural protein 3, NS3, is a nonstructural protein possessing serine protease, helicase, and NTPase activity, it is a key player in virus replication. Ability of NS3 of classical swine fever virus to compensate for disabling size increase of core protein, role of NS3 in particle assembly, overview. In addition to its essential role in RNA replication, NS3 apparently organizes the incorporation of RNA into budding virus particles	Classical swine fever virus

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Release 2023.1 (January 2023)