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Literature summary for 3.4.21.112 extracted from

  • Weiss, N.; Stegemann, A.; Elsayed, M.A.; Schallreuter, K.U.; Luger, T.A.; Loser, K.; Metze, D.; Weishaupt, C.; Boehm, M.
    Inhibition of the prohormone convertase subtilisin-kexin isoenzyme-1 induces apoptosis in human melanoma cells (2014), J. Invest. Dermatol., 134, 168-175.
    View publication on PubMed

Application

Application Comment Organism
medicine the enzyme is a potential target for melanoma therapy Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
decanoyl-RRLL-chloromethylketone the selective and cell-permeable small-peptide inhibitor inhibits the enzyme and leads to suppression of proliferation and metabolic activity of melanoma cells in vitro. The inhibitor induces classical apoptosis of melanoma cells in vitro and affects expression of several SKI-1 target genes including activating transcription factor 6. The compound induces cell death in an ATF6-independent manner Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
100000
-
x * 100000, about, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14703
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-375 cell
-
Homo sapiens
-
G-361 cell
-
Homo sapiens
-
Hep-G2 cell
-
Homo sapiens
-
IGR-37 cell
-
Homo sapiens
-
IPC298 cell
-
Homo sapiens
-
melanoma cell the enzyme SKI-1 is constitutively expressed in human pigment cells with higher SKI activity in seven out of eight melanoma cell lines compared with normal melanocytes, also detectable in tumor cells of melanoma metastases Homo sapiens
-
additional information subtilisin-kexin isoenzyme-1 (SKI-1) expression and activity in human pigment cells in vitro, as well as in normal human skin and metastatic melanoma, overview Homo sapiens
-
SK-MEl-30 cell
-
Homo sapiens
-
skin
-
Homo sapiens
-
WM-35 cell
-
Homo sapiens
-
WM-9 cell
-
Homo sapiens
-
WM-902B cell
-
Homo sapiens
-

Subunits

Subunits Comment Organism
? x * 100000, about, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
prohormone convertase subtilisin-kexin isoenzyme-1
-
Homo sapiens
SKI-1
-
Homo sapiens
subtilisin-kexin isoenzyme-1
-
Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme SKI-1 inhibition induces apoptosis of melanoma cells by a non-ATF6-dependent mechanism, overview Homo sapiens
physiological function the enzyme regulates cartilage development, bone mineralization, and processing of viral glycoproteins, its overexpression is linked to carcinogenesis in some solid tumors, biological role of enzyme SKI-1 in melanoma development, overview Homo sapiens