Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a potential target for melanoma therapy | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
decanoyl-RRLL-chloromethylketone | the selective and cell-permeable small-peptide inhibitor inhibits the enzyme and leads to suppression of proliferation and metabolic activity of melanoma cells in vitro. The inhibitor induces classical apoptosis of melanoma cells in vitro and affects expression of several SKI-1 target genes including activating transcription factor 6. The compound induces cell death in an ATF6-independent manner | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
100000 | - |
x * 100000, about, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q14703 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-375 cell | - |
Homo sapiens | - |
G-361 cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
IGR-37 cell | - |
Homo sapiens | - |
IPC298 cell | - |
Homo sapiens | - |
melanoma cell | the enzyme SKI-1 is constitutively expressed in human pigment cells with higher SKI activity in seven out of eight melanoma cell lines compared with normal melanocytes, also detectable in tumor cells of melanoma metastases | Homo sapiens | - |
additional information | subtilisin-kexin isoenzyme-1 (SKI-1) expression and activity in human pigment cells in vitro, as well as in normal human skin and metastatic melanoma, overview | Homo sapiens | - |
SK-MEl-30 cell | - |
Homo sapiens | - |
skin | - |
Homo sapiens | - |
WM-35 cell | - |
Homo sapiens | - |
WM-9 cell | - |
Homo sapiens | - |
WM-902B cell | - |
Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
? | x * 100000, about, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
prohormone convertase subtilisin-kexin isoenzyme-1 | - |
Homo sapiens |
SKI-1 | - |
Homo sapiens |
subtilisin-kexin isoenzyme-1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme SKI-1 inhibition induces apoptosis of melanoma cells by a non-ATF6-dependent mechanism, overview | Homo sapiens |
physiological function | the enzyme regulates cartilage development, bone mineralization, and processing of viral glycoproteins, its overexpression is linked to carcinogenesis in some solid tumors, biological role of enzyme SKI-1 in melanoma development, overview | Homo sapiens |