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Literature summary for 3.4.21.112 extracted from
- Site 1 protease is required for proteolytic processing of the glycoproteins of the South American hemorrhagic fever viruses Junin, Machupo, and Guanarito (2008), J. Virol., 82, 6045-6051.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | using SRD12B mutant cells lacking the S1P gene, it is shown that lack of glycoprotein processing of Junin virus dramatically reduces production of infectious virus and prevents cell-to-cell propagation. Infection of S1P-deficient cells results in viral persistence over several weeks without the emergence of escape variants able to use other cellular proteases for GP processing | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glycoprotein + H2O | S1P is involved in the processing of the glycoproteins of the genetically more-distant South American hemorrhagic fever viruses Guanarito, Machupo, and Junin | Homo sapiens | ? | - |
? |  |
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Release 2023.1 (January 2023)
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