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Literature summary for 3.4.21.112 extracted from

  • De Windt, A.; Rai, M.; Bernier, L.; Thelen, K.; Soini, J.; Lefebvre, C.; Chintawar, S.; Lavigne, J.; Saarinen, L.; Kytoemaeki, L.; Munzer, J.S.; Luetjohann, D.; Pandolfo, M.; Davignon, J.; Seidah, N.G.; Laaksonen, R.
    Gene Set Enrichment Analysis Reveals Several Globally Affected Pathways due to SKI-1/S1P Inhibition in HepG2 Cells (2007), DNA Cell Biol., 26, 765-772.
    View publication on PubMed
Search for more literature for 3.4.21.112

Application

Application Comment Organism
medicine useful role of SKI-1/S1P in controlling cholesterol synthesis, particularly in the presence of endoplasmic reticulum stress. SKI-1/S1P inhibition may be a potential tool for the treatment of alcohol-induced liver steatosis Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of proSKI variants in HepG2 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
R130A/K131A proSKI variant that exhibits no basic residue at the P4 position, has no effect on HMG-CoA reductase mRNA levels Homo sapiens
R134E proSKI variant that lacks autocatalytic primary cleavage site RSLK, most efficient inhibitor of HMG-CoA reductase expression Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information SKI-1/S1P inhibition by overexpression of proSKI variants, results in reduced cholesterol synthesis and mRNA levels of the rate-limiting enzymes HMG-CoA reductase and squalene epoxidase in the cholesterol synthetic pathway. Inhibitory effect is maintained in the presence of homocysteine-induced endoplasmic reticulum stress. SKI-1/S1P inhibition also affects glycolysis and citric acid cycle Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
SKI-1/S1P
-
 Homo sapiens