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Literature summary for 3.4.21.112 extracted from
- Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6 (2004), J. Biol. Chem., 279, 43046-43051.
Application
| Application | Comment | Organism |
|---|---|---|
| degradation | S1P reduces the size of the luminal domain to prepare ATF6 to be an optimal S2P substrate | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-(2-aminoethyl)-benzenesulfonyl fluoride | - |
Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | relocalization of SP1 and SP2 with brefeldin A, reconstitution of the sequential cleavage of ATF6 | Homo sapiens | 5783 | - |
| Golgi apparatus | SP1 localizes to the same compartment as SP2, the cis/medial Golgi | Homo sapiens | 5794 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATF6 + H2O | i.e. activating transcription factor 6 | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| S1P | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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