Literature summary for 3.4.21.110 extracted from

Cleary, P.P.; Matsuka, Y.V.; Huynh, T.; Lam, H.; Olmsted, S.B.
Immunization with C5a peptidase from either group A or B streptococci enhances clearance of group A streptococci from intranasally infected mice (2004), Vaccine, 22, 4332-4341.

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Application

Application	Comment	Organism
medicine	immunization with C5a peptidase protein from either group A or group B streptococci provides protection against group A streptococcus infections in mice, moreover, mice immunized with antibodies directed against protein from group B streptococci also cleared streptococci from their lungs more efficiently than those immunized with tetanus toxoid	Streptococcus pyogenes

Protein Variants

Protein Variants	Comment	Organism
D130A/S512A	no hydrolysis of substrate	Streptococcus pyogenes

Organism

Organism	UniProt	Comment	Textmining
Streptococcus pyogenes	-	group A streptococcal serotype M1 strains 90-131, 90-226 and MGAS5005, serotype M49 strain CS101	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Ac-SQLRANISH-p-nitroanilide + H2O	-	Streptococcus pyogenes	?	-	?

Synonyms

Synonyms	Comment	Organism
SCPA	-	Streptococcus pyogenes
ScpB	-	Streptococcus pyogenes

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Release 2023.1 (January 2023)