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Literature summary for 3.4.21.109 extracted from

  • Clark, E.B.; Jovov, B.; Rooj, A.K.; Fuller, C.M.; Benos, D.J.
    Proteolytic cleavage of human acid-sensing ion channel 1 by the serine protease matriptase (2010), J. Biol. Chem., 285, 27130-27143.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.109

Cloned(Commentary)

Cloned (Comment) Organism
co-expressed Xenopus laevis oocytes and CHO K1 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
S805A inactive Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane matriptase is a type II transmembrane serine protease Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
 x * 70000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acid-sensing ion channel 1 + H2O Homo sapiens the matriptase recognition sites Arg-145, Lys-185, and Lys-384 are identified in the specific substrate acid-sensing ion channel 1 ?
-
 ?
additional information Homo sapiens matriptase does not cleave acid-sensing ion channel 2 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Homo sapiens
-
D-54MG cell
-
 Homo sapiens
-
epithelium
-
 Homo sapiens
-
glioma cell
-
 Homo sapiens
-
SK-MG-1 cell
-
 Homo sapiens
-
U-251MG cell
-
 Homo sapiens
-
U-87MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acid-sensing ion channel 1 + H2O the matriptase recognition sites Arg-145, Lys-185, and Lys-384 are identified in the specific substrate acid-sensing ion channel 1 Homo sapiens ?
-
 ?
additional information matriptase does not cleave acid-sensing ion channel 2 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 70000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
matriptase-1
-
 Homo sapiens
membrane-type serine protease-1
-
 Homo sapiens
MT-SP1
-
 Homo sapiens