Literature summary for 3.4.21.109 extracted from

Napp, J.; Dullin, C.; Mueller, F.; Uhland, K.; Petri, J.B.; van de Locht, A.; Steinmetzer, T.; Alves, F.
Time-domain in vivo near infrared fluorescence imaging for evaluation of matriptase as a potential target for the development of novel, inhibitor-based tumour therapies (2010), Int. J. Cancer, 127, 1958-1974.

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Application

Application	Comment	Organism
medicine	time-domain near infrared fluorescence (NIRF) imaging is applied to characterize expression and activity of matriptase in vivo in an orthotopic AsPC-1 pancreatic tumor model in nude mice. Strong expression and tumor-specific binding of intravenously injected antimatriptase antibody only to primary AsPC-1 tumors and their metastases is shown. Using a synthetic substrate it is shown that matriptase is proteolytically active in vitro as well as in vivo in tumor-bearing mice, and that application of synthetic active-site inhibitors can efficiently inhibit its proteolytic activity for at least 24 h	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
95000	-	Western blot analysis, reducing conditions	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MDA-MB-435 cell	RT-PCR analysis reveal a 1000fold higher matriptase expression in human pancreatic adenocarcinoma AsPC-1 cells than in the MDA-MB-435S cells	Homo sapiens	-
PC-1 cell	RT-PCR analysis reveal a 1000fold higher matriptase expression in human pancreatic adenocarcinoma AsPC-1 cells than in the MDA-MB-435S cells	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(DY-681)-Gly-Arg-Gln-Ser-Arg-Ala-Ile-Lys (DY-681)-NH + H2O	synthetic substrate, peptide sequence is derived from one of the preferred matriptase cleavage sequences, P4(Arg/Lys)-P3(Xxx)-P2(Ser)-P1(Arg)-P10(Ala), where Xxx is a nonbasic amino acid	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
matriptase	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	RT-PACR analysis reveal a 1000fold higher matriptase expression in human pancreatic adenocarcinoma AsPC-1 cells than in the MDA-MB-435S cells	up

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Release 2023.1 (January 2023)