Literature summary for 3.4.21.109 extracted from

Tsuzuki, S.; Murai, N.; Miyake, Y.; Inouye, K.; Fushiki, T.
The structural requirements of matriptase in its ectodomain release in polarized epithelial cells (2010), Biosci. Biotechnol. Biochem., 74, 1295-1297.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Madin-Darby canine kidney cell line as a full-length rat matriptase with Myc-epitope-hexahistidine tag at its carboxyl-terminus	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
DELTA1-603	variant in which the catalytic domain and its N-terminal spacer region (Cys604-Val855) are deleted from matriptase: variant indicates that the catalytic domain is critical for the release of the C-terminal fragment from the cell surface	Rattus norvegicus
G149N	mutant G149 fused to Myc-epitope-hexahistidine tag at its carboxyl-terminus. This mutant is impaired with respect to the generation of an N-terminus at Ser-150. When probed with an anti-Myc antibody no signals for matriptase C-terminal fragment is detected	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	matriptase is processed post-translationally via cleavage between Gly149 and Ser150, the C-terminal fragment Ser150-Val855 is released from the cell surface	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
matriptase	-	Rattus norvegicus

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Release 2023.1 (January 2023)