Protein Variants | Comment | Organism |
---|---|---|
additional information | genetic ablation of the enzyme in hepatocyte growth factor activator inhibitor-1-deficient embryos restores the integrity of chorionic trophoblasts and enables placental labyrinth formation and development in turn, which otherwise is prevented, overview, phenotype of single enzyme knockout and double enzyme and inhibitor knockout mutant embryos, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
hepatocyte growth factor activator inhibitor-1 | HAI-1, a Kunitz-type transmembrane serine protease inhibitor, complex formation with the enzyme, enzyme inhibition is essential for placental development, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development, mechanism, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | the enzyme is co-expressed with hepatocyte growth factor activator inhibitor-1 in both extraembryonic and embryonic tissue | Mus musculus | - |
additional information | the enzyme is co-expressed with hepatocyte growth factor activator inhibitor-1 in both extraembryonic and embryonic tissue, overview | Mus musculus | - |
placenta | enzyme inhibition is essential for placental development, overview | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development, mechanism, overview | Mus musculus | ? | - |
? |