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Literature summary for 3.4.21.109 extracted from

  • Li, P.; Jiang, S.; Lee, S.L.; Lin, C.Y.; Johnson, M.D.; Dickson, R.B.; Michejda, C.J.; Roller, P.P.
    Design and synthesis of novel and potent inhibitors of the type II transmembrane serine protease, matriptase, based upon the sunflower trypsin inhibitor-1 (2007), J. Med. Chem., 50, 5976-5983.
    View publication on PubMed
Search for more literature for 3.4.21.109

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibitor design and synthesis, inhibitory potency and structure-activity relationships, overview, matriptase blockade could potentially modulate tumorigenesis and metastasis in vivo Homo sapiens
sunflower trypsin inhibitor-1 and several derivatives with different amino acid side chains, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane matriptase is a type II transmembrane protein Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens matriptase blockade could potentially modulate tumorigenesis and metastasis in vivo ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information matriptase blockade could potentially modulate tumorigenesis and metastasis in vivo Homo sapiens ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0001
-
 sunflower trypsin inhibitor-1
-
 Homo sapiens