Protein Variants | Comment | Organism |
---|---|---|
additional information | null mice show impaired development of the hair follicles and immune system and are unable to survive 48 hours past birth due to rapid dehydration through an abnormally formed epidermal barrier | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
hepatocyte growth factor activator inhibitor-1 | is required for proper development of placenta, overview | Homo sapiens | |
hepatocyte growth factor activator inhibitor-1 | is required for proper development of placenta, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | MT-SP1 is a type II transmembrane serine protease | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
HGF/SF + H2O | Homo sapiens | i.e. hepatocyte growth factor/scatter factor, growth factor | ? | - |
? | |
IGFBP-rP1 + H2O | Homo sapiens | an adhesion factor | ? | - |
? | |
additional information | Homo sapiens | physiological functions, overview, MT-SP1 is a type II transmembrane serine protease implicated in a range of cancers including those of the breast, cervix, ovaries, prostate, colon and gastrointestinal tract, MT-SP1 plays a role in embryologic development | ? | - |
? | |
additional information | Mus musculus | physiological functions, overview, MT-SP1 is critical for proper epidermal development and postnatal survival, MT-SP1 plays a role in embryologic development | ? | - |
? | |
MSP-1 + H2O | Homo sapiens | i.e. macrophage-stimulating protein 1, a growth factor | ? | - |
? | |
PAR-2 + H2O | Mus musculus | G-protein coupled receptor | ? | - |
? | |
PAR-2 + H2O | Homo sapiens | G-protein coupled receptor | ? | - |
? | |
prostasin + H2O | Mus musculus | a serine protease | ? | - |
? | |
prostasin + H2O | Homo sapiens | a serine protease | ? | - |
? | |
serine protease uPA + H2O | Mus musculus | - |
? | - |
? | |
serine protease uPA + H2O | Homo sapiens | - |
? | - |
? | |
trask + H2O | Homo sapiens | a transmembrane glycoprotein | ? | - |
? | |
VEGFR-2 + H2O | Mus musculus | i.e. vascular endothelial growth factor receptor 2, a growth factor receptor | ? | - |
? | |
VEGFR-2 + H2O | Homo sapiens | i.e. vascular endothelial growth factor receptor 2, a growth factor receptor | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene ST14 | - |
Mus musculus | - |
gene ST14 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | MT-SP1 is activated by cleavage at Arg614 with the catalytic domain remaining attached to the upstream domains via a disulfide bond, the activation cleavage sequence of MT-SP1 is RXQXAXRXXV, MT-SP1 is able to autoactivate both in solution in the membrane-bound form | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast | - |
Homo sapiens | - |
breast cancer cell | - |
Homo sapiens | - |
cervix | - |
Homo sapiens | - |
colon | - |
Homo sapiens | - |
gastrointestinal tract | - |
Homo sapiens | - |
ovary | - |
Homo sapiens | - |
prostate | - |
Homo sapiens | - |
prostate cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
HGF/SF + H2O | i.e. hepatocyte growth factor/scatter factor, growth factor | Homo sapiens | ? | - |
? | |
IGFBP-rP1 + H2O | an adhesion factor | Homo sapiens | ? | - |
? | |
additional information | substrate specificity, overview | Mus musculus | ? | - |
? | |
additional information | substrate specificity, overview | Homo sapiens | ? | - |
? | |
additional information | physiological functions, overview, MT-SP1 is a type II transmembrane serine protease implicated in a range of cancers including those of the breast, cervix, ovaries, prostate, colon and gastrointestinal tract, MT-SP1 plays a role in embryologic development | Homo sapiens | ? | - |
? | |
additional information | physiological functions, overview, MT-SP1 is critical for proper epidermal development and postnatal survival, MT-SP1 plays a role in embryologic development | Mus musculus | ? | - |
? | |
MSP-1 + H2O | i.e. macrophage-stimulating protein 1, a growth factor | Homo sapiens | ? | - |
? | |
PAR-2 + H2O | G-protein coupled receptor | Mus musculus | ? | - |
? | |
PAR-2 + H2O | G-protein coupled receptor | Homo sapiens | ? | - |
? | |
prostasin + H2O | a serine protease | Mus musculus | ? | - |
? | |
prostasin + H2O | a serine protease | Homo sapiens | ? | - |
? | |
serine protease uPA + H2O | - |
Mus musculus | ? | - |
? | |
serine protease uPA + H2O | - |
Homo sapiens | ? | - |
? | |
trask + H2O | a transmembrane glycoprotein | Homo sapiens | ? | - |
? | |
trask + H2O | i.e. CDCP1 or SIMA 135, a transmembrane glycoprotein | Homo sapiens | ? | - |
? | |
VEGFR-2 + H2O | i.e. vascular endothelial growth factor receptor 2, a growth factor receptor | Mus musculus | ? | - |
? | |
VEGFR-2 + H2O | i.e. vascular endothelial growth factor receptor 2, a growth factor receptor | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
epithin | - |
Mus musculus |
epithin | - |
Homo sapiens |
matriptase | - |
Mus musculus |
matriptase | - |
Homo sapiens |
MT-SP1 | - |
Mus musculus |
MT-SP1 | - |
Homo sapiens |
prostamin | - |
Mus musculus |
prostamin | - |
Homo sapiens |
PRSS14 | - |
Mus musculus |
PRSS14 | - |
Homo sapiens |
SNC19 | - |
Mus musculus |
SNC19 | - |
Homo sapiens |
TADG-15 | - |
Mus musculus |
TADG-15 | - |
Homo sapiens |