Any feedback?
Literature summary for 3.4.21.109 extracted from
- Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis (2007), Development, 134, 3461-3471.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | enzyme and hepatocyte growth factor activator inhibitor-1, Hai1, deficient phenotype, hai1 mutant defects are rescued by inactivation of matriptase1a, overview | Danio rerio |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| hepatocyte growth factor activator inhibitor-1 | Hai1a, i.e. Spint1Ia, enzyme inactivation by HAI-1 is required for epithelial integrity of the zebrafish epidermis, inhibitor mutant zebrafish show disrupted epidermal integrity, enhanced upon combined loss of hai1a and the paralogue hai1b, overview | Danio rerio |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Danio rerio | enzyme inactivation by HAI-1 is required for epithelial integrity of the zebrafish epidermis, Hai1 and matriptase1a are involved in regualtion of skin homeostasis and remodeling, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Danio rerio | - |
zebrafish | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epidermis | enzyme expression in developing basal layer of the epidermis, enzyme inactivation by HAI-1 is required for epithelial integrity of the zebrafish epidermis, overview | Danio rerio | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | enzyme inactivation by HAI-1 is required for epithelial integrity of the zebrafish epidermis, Hai1 and matriptase1a are involved in regualtion of skin homeostasis and remodeling, overview | Danio rerio | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| matriptase1 | - |
Danio rerio |
| matriptase1a | - |
Danio rerio |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
