Cloned (Comment) | Organism |
---|---|
overexpression of matriptase-2 in MDA-MB-231 cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
membrane | transmembrane type II protein | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | matriptase-1 enhances breast tumor growth and invasion and correlates with poor prognosis for breast cancer patients, while matriptase-2 shows the opposite effects, overview | ? | - |
? | |
additional information | Homo sapiens | matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients, while matriptase-1 shows the opposite effects, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | Q9Y5Y6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
breast cancer cell | - |
Homo sapiens | - |
BT-474 cell | - |
Homo sapiens | - |
BT-474 cell | high expression level | Homo sapiens | - |
BT-549 cell | low expression level | Homo sapiens | - |
CA-HPV-10 cell | - |
Homo sapiens | - |
DU-145 cell | - |
Homo sapiens | - |
HRT-18 cell | - |
Homo sapiens | - |
HT-115 cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
additional information | matriptase-1 expression analysis, no matriptase-1 expression in cell lines: MDA-MB-157, MDA-MB-436, MDA-MB-453, MDA-MB-43S5, IRB.3.G, MIA-PACA-2, EJ-138, T-24, G-361, ECV-304, PLC-PRF-5, and in endothelial cells, overview | Homo sapiens | - |
additional information | matriptase-2 expression analysis, no matriptase-2 expression in cell lines: MDA-MB-157, MDA-MB-231, MDA-MB-436, MDA-MB-453, MDA-MB-43S5, BT549, PC-3, DU-145, CA-HPV-10, HT-115, HRT-18, MRC5, IRB.3.G, MIA-PACA-2, EJ-138, T-24, A-549, G-361, ECV-304, and in endothelial cells, overview | Homo sapiens | - |
MRC-5 cell | low expression level | Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
PLC-PRF-5 cell | - |
Homo sapiens | - |
ZR-75-1 cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
quantitative expression analysis of matriptase-1 in breast cancer samples, overview | Homo sapiens |
additional information | - |
quantitative expression analysis of matriptase-2 in breast cancer samples, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | matriptase-1 enhances breast tumor growth and invasion and correlates with poor prognosis for breast cancer patients, while matriptase-2 shows the opposite effects, overview | Homo sapiens | ? | - |
? | |
additional information | matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients, while matriptase-1 shows the opposite effects, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matriptase-1 | - |
Homo sapiens |
matriptase-2 | - |
Homo sapiens |