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Literature summary for 3.4.21.109 extracted from

  • Parr, C.; Sanders, A.J.; Davies, G.; Martin, T.; Lane, J.; Mason, M.D.; Mansel, R.E.; Jiang, W.G.
    Matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients (2007), Clin. Cancer Res., 13, 3568-3576.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of matriptase-2 in MDA-MB-231 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
Homo sapiens 9986
-
membrane transmembrane type II protein Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens matriptase-1 enhances breast tumor growth and invasion and correlates with poor prognosis for breast cancer patients, while matriptase-2 shows the opposite effects, overview ?
-
?
additional information Homo sapiens matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients, while matriptase-1 shows the opposite effects, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens Q9Y5Y6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
breast cancer cell
-
Homo sapiens
-
BT-474 cell
-
Homo sapiens
-
BT-474 cell high expression level Homo sapiens
-
BT-549 cell low expression level Homo sapiens
-
CA-HPV-10 cell
-
Homo sapiens
-
DU-145 cell
-
Homo sapiens
-
HRT-18 cell
-
Homo sapiens
-
HT-115 cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-
additional information matriptase-1 expression analysis, no matriptase-1 expression in cell lines: MDA-MB-157, MDA-MB-436, MDA-MB-453, MDA-MB-43S5, IRB.3.G, MIA-PACA-2, EJ-138, T-24, G-361, ECV-304, PLC-PRF-5, and in endothelial cells, overview Homo sapiens
-
additional information matriptase-2 expression analysis, no matriptase-2 expression in cell lines: MDA-MB-157, MDA-MB-231, MDA-MB-436, MDA-MB-453, MDA-MB-43S5, BT549, PC-3, DU-145, CA-HPV-10, HT-115, HRT-18, MRC5, IRB.3.G, MIA-PACA-2, EJ-138, T-24, A-549, G-361, ECV-304, and in endothelial cells, overview Homo sapiens
-
MRC-5 cell low expression level Homo sapiens
-
PC-3 cell
-
Homo sapiens
-
PLC-PRF-5 cell
-
Homo sapiens
-
ZR-75-1 cell
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
quantitative expression analysis of matriptase-1 in breast cancer samples, overview Homo sapiens
additional information
-
quantitative expression analysis of matriptase-2 in breast cancer samples, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information matriptase-1 enhances breast tumor growth and invasion and correlates with poor prognosis for breast cancer patients, while matriptase-2 shows the opposite effects, overview Homo sapiens ?
-
?
additional information matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients, while matriptase-1 shows the opposite effects, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
matriptase-1
-
Homo sapiens
matriptase-2
-
Homo sapiens