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Literature summary for 3.4.21.109 extracted from

  • Szabo, R.; Netzel-Arnett, S.; Hobson, J.P.; Antalis, T.M.; Bugge, T.H.
    Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity (2005), Biochem. J., 290, 231-242.
No PubMed abstract available
Search for more literature for 3.4.21.109

Cloned(Commentary)

Cloned (Comment) Organism
activated matriptase-3 serine protease domain expressed in insect cells, expression in COS7 cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
alpha1 proteinase formation of a stable inhibitor complex Mus musculus
alpha2-antiplasmin formation of a stable inhibitor complex Mus musculus
antithrombin III formation of a stable inhibitor complex Mus musculus
hepatocyte growth factor activator inhibitor I
-
 Mus musculus
plasminogen activator inhibitor-1 formation of a stable inhibitor complex Mus musculus
Protein C inhibitor formation of a stable inhibitor complex Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
240
-
 Suc-Ala-Ala-Pro-Arg-p-nitroanilide
-
 Mus musculus
534
-
 Suc-Ala-Ala-Pro-Lys-p-nitroanilide
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Mus musculus 9986
-
membrane transmembrane protein, composed of a short N-terminal cytoplasmic region followed by a transmembrane domain Mus musculus 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
90000
-
 x * 90000, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein N-glycosylated Mus musculus

Purification (Commentary)

Purification (Comment) Organism
activated matriptase-3 serine protease domain expressed in Spodoptera frugiperda Sf9 cells Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
brain
-
 Homo sapiens
-
epididymis
-
 Mus musculus
-
eye
-
 Mus musculus
-
heart
-
 Mus musculus
-
lung
-
 Homo sapiens
-
ovary
-
 Mus musculus
-
ovary
-
 Homo sapiens
-
prostate
-
 Mus musculus
-
salivary gland
-
 Mus musculus
-
salivary gland
-
 Homo sapiens
-
skeletal muscle
-
 Mus musculus
-
skin
-
 Mus musculus
-
testis
-
 Mus musculus
-
testis
-
 Homo sapiens
-
thymus
-
 Mus musculus
-
trachea
-
 Homo sapiens
-
uterus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Bovine serum albumin + H2O
-
 Mus musculus ?
-
 ?
casein + H2O
-
 Mus musculus ?
-
 ?
denatured collagen + H2O
-
 Mus musculus ?
-
 ?
H-Glu-Gly-Arg-p-nitroanilide + H2O low activity Mus musculus H-Glu-Gly + Arg-p-nitroanilide
-
 ?
Suc-Ala-Ala-Pro-Arg-p-nitroanilide + H2O low activity Mus musculus Suc-Ala-Ala-Pro + Arg-p-nitroanilide
-
 ?
Suc-Ala-Ala-Pro-Lys-p-nitroanilide + H2O
-
 Mus musculus Suc-Ala-Ala-Pro-Lys + p-nitroaniline
-
 ?
Z-Phe-Val-Arg-p-nitroanilide + H2O
-
 Mus musculus Z-Phe-Val + Arg-p-nitroanilide
-
 ?

Subunits

Subunits Comment Organism
? x * 90000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
matriptase-3
-
 Mus musculus
matriptase-3
-
 Homo sapiens