Inhibitors | Comment | Organism | Structure |
---|---|---|---|
UCF101 | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | HtrA2 is a mitochondrial protease | Homo sapiens | 5739 | - |
nucleus | HtrA2 is also present at low levels in the nucleus | Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Wilms' tumor suppressor 1 + H2O | Homo sapiens | bona fide substrate for HtrA2-mediated proteolysis, cleavage sites are in the C terminus at Val286 and Leu320, resulting in fragments of 20000 and 35000 Da, respectively, while another cleavage site is in the N terminus at Leu91 adjacent to suppression domain | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Wilms' tumor suppressor 1 + H2O | bona fide substrate for HtrA2-mediated proteolysis, cleavage sites are in the C terminus at Val286 and Leu320, resulting in fragments of 20000 and 35000 Da, respectively, while another cleavage site is in the N terminus at Leu91 adjacent to suppression domain | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
high temperature requirement protein A2 | - |
Homo sapiens |
HtrA2/Omi | - |
Homo sapiens |