Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ucf-101 | treatment of lung epithelial adenocarcinoma cell A549 decreases the cleavage of annexin A2 under both serum withdrawal and cisplatin treatment | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | Omi/HtrA2 relocates from mitochondria to the cytosol in lung adenocarcinoma cell line A549 under serum withdrawal | Homo sapiens | 5829 | - |
mitochondrion | immunostaining and confocal microscopy shows that Omi/HtrA2 is located primarily in the mitochondria of lung adenocarcinoma cell line A549 | Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung adenocarcinoma cell line | human lung epithelial adenocarcinoma cell A549 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
X-linked inhibitor of apoptosis protein + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Omi/HtrA2 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | Omi/HtrA2 siRNA decreases the cleavage of annexin A2 lung epithelial adenocarcinoma cell A549 under both serum withdrawal and cisplatin treatment | down |
General Information | Comment | Organism |
---|---|---|
physiological function | Omi/HtrA2 is released from mitochondria to the cytosol and is required for annexin A2 cleavage under apoptotic stimuli | Homo sapiens |