Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
parkin + H2O | Mus musculus | HtrA2/Omi cleaves E3 ubiquitin ligase Parkin | ? | - |
? | |
parkin + H2O | Homo sapiens | using cleavage and binding assays, it is demonstrated that HtrA2 specifically binds to and directly cleaves the E3 ubiquitin ligase Parkin | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
parkin + H2O | HtrA2/Omi cleaves E3 ubiquitin ligase Parkin | Mus musculus | ? | - |
? | |
parkin + H2O | using cleavage and binding assays, it is demonstrated that HtrA2 specifically binds to and directly cleaves the E3 ubiquitin ligase Parkin | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HtrA2 | - |
Mus musculus |
HtrA2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | endogenous levels of Parkin are significantly decreased in wild-type (HtrA2+/+) mouse embryonic fibroblasts compared with those in HtrA2-knockout (HtrA2-/-) mouse embryonic fibroblasts under the same stress conditions | Mus musculus |
physiological function | the HtrA2-mediated Parkin cleavage irreversibly disrupts Parkin-mediated synphilin-1 ubiquitination and autoubiquitination, indicating that HtrA2 may play a critical role in the Parkin-related pathway involved in the ubiquitin proteasome system | Homo sapiens |