Literature summary for 3.4.21.108 extracted from

Yun, J.; Cao, J.H.; Dodson, M.W.; Clark, I.E.; Kapahi, P.; Chowdhury, R.B.; Guo, M.
Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo (2008), J. Neurosci., 28, 14500-14510.

Search for more literature for 3.4.21.108

Application

Application	Comment	Organism
medicine	mutations in the OMI/HTRA2 gene are linked to Parkinsons disease	Drosophila melanogaster

Cloned(Commentary)

Cloned (Comment)	Organism
into the vectors pUASt and pTMR	Drosophila melanogaster

Protein Variants

Protein Variants	Comment	Organism
G363S	Drosophila Omi mutant analogous to human Omi/HtrA2 mutation G399S	Drosophila melanogaster
S236C	Drosophila Omi mutant analogous to human Omi/HtrA2 mutation S276C	Drosophila melanogaster
S266A	Drosophila Omi mutant analogous to human Omi/HtrA2 mutation S306A	Drosophila melanogaster
S364A	Drosophila Omi mutant analogous to human Omi/HtrA2 mutation S400A	Drosophila melanogaster

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	released into the cytosol upon apoptotic stimuli	Drosophila melanogaster	5829	-
mitochondrial intermembrane space	-	Drosophila melanogaster	5758	-
mitochondrion	-	Drosophila melanogaster	5739	-

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	Q9VFJ3	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	-	Drosophila melanogaster

Source Tissue

Source Tissue	Comment	Organism	Textmining
eye	-	Drosophila melanogaster	-

Synonyms

Synonyms	Comment	Organism
Omi/HtrA2	-	Drosophila melanogaster
serine protease	-	Drosophila melanogaster

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Release 2023.1 (January 2023)