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Literature summary for 3.4.21.108 extracted from

  • Han, C.; Nam, M.K.; Park, H.J.; Seong, Y.M.; Kang, S.; Rhim, H.
    Tunicamycin-induced ER stress upregulates the expression of mitochondrial HtrA2 and promotes apoptosis through the cytosolic release of HtrA2 (2008), J. Microbiol. Biotechnol., 18, 1197-1202.
    View publication on PubMed
Search for more literature for 3.4.21.108

Activating Compound

Activating Compound Comment Organism Structure
additional information HtrA2 protein level is gradually and significantly increased by up to 10fold in the mitochondria under tunicamycin-induced ER stress Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
yes into the ecdysone-inducible eukaryotic expression vector pIND Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol released into the cytosol upon apoptotic stimuli Homo sapiens 5829
-
mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37400
-
 mature HtrA2, determined by SDS-PAGE and Western blot analysis Homo sapiens
49500
-
 HtrA2 precursor, determined by SDS-PAGE and Western blot analysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
mitochondrial fractions of HEK-293T cells are prepared Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
HEK-293T cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
HtrA2
-
 Homo sapiens