Application | Comment | Organism |
---|---|---|
medicine | the relation between p73 and HtrA2 may help to understand the behavior of the p73 protein in the responses of cancer cells to chemotherapy | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
into the vector pCMV/SPORT | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S306A | proteolytically inactive mutant | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
HtrA2 siRNA | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | healthy cell | Homo sapiens | 5739 | - |
nucleus | following apoptotic stimuli, HtrA2 accumulates in the nucleus | Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | HtrA2 cleaves p73alpha in the C-terminal portion | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HCT-116 cell | - |
Homo sapiens | - |
NCI-H1299 cell | human non-small-cell lung carcinoma cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | HtrA2 cleaves p73alpha in the C-terminal portion | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HtrA2 | - |
Homo sapiens |
serine protease | - |
Homo sapiens |