Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | focal cerebral ischemia/reperfusion induces a mitochondrial up-regulation of Omi/HtrA2 and significantly increases cytosolic accumulation of Omi/HtrA2 | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | Omi/HtrA2 is involved in neuronal cell death following focal cerebral ischemia/reperfusion. Blocking the proteolytic activity of Omi/HtrA2 with specific inhibitors, such as the ucf-101, may be a way to afford neuroprotection and minimize cellular damage in cerebral ischemia/reperfusion | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ucf-101 | specific inhibitor of Omi/HtrA2. Reduces the number of TUNEL-positive cells, attenuates the X-linked inhibitor of apoptosis protein-breakdown and reduces the infarct size | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | focal cerebral ischemia in rats results in Omi/HtrA2 translocation from the mitochondria to the cytosol | Rattus norvegicus | 5829 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
X-linked inhibitor of apoptosis protein + H2O | - |
Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Omi/HtrA2 | - |
Rattus norvegicus |
serine protease Omi/HtrA2 | - |
Rattus norvegicus |