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Literature summary for 3.4.21.108 extracted from

  • Althaus, J.; Siegelin, M.D.; Dehghani, F.; Cilenti, L.; Zervos, A.S.; Rami, A.
    The serine protease Omi/HtrA2 is involved in XIAP cleavage and in neuronal cell death following focal cerebral ischemia/reperfusion (2007), Neurochem. Int., 50, 172-180.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information focal cerebral ischemia/reperfusion induces a mitochondrial up-regulation of Omi/HtrA2 and significantly increases cytosolic accumulation of Omi/HtrA2 Rattus norvegicus

Application

Application Comment Organism
medicine Omi/HtrA2 is involved in neuronal cell death following focal cerebral ischemia/reperfusion. Blocking the proteolytic activity of Omi/HtrA2 with specific inhibitors, such as the ucf-101, may be a way to afford neuroprotection and minimize cellular damage in cerebral ischemia/reperfusion Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
ucf-101 specific inhibitor of Omi/HtrA2. Reduces the number of TUNEL-positive cells, attenuates the X-linked inhibitor of apoptosis protein-breakdown and reduces the infarct size Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol focal cerebral ischemia in rats results in Omi/HtrA2 translocation from the mitochondria to the cytosol Rattus norvegicus 5829
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mitochondrion
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Rattus norvegicus 5739
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
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Rattus norvegicus
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neuron
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Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
X-linked inhibitor of apoptosis protein + H2O
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Rattus norvegicus ?
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?

Synonyms

Synonyms Comment Organism
Omi/HtrA2
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Rattus norvegicus
serine protease Omi/HtrA2
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Rattus norvegicus