Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli and MEF cells from mnd2 mouse | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
L286V | Alzheimer mutant presenilin-1 | Homo sapiens |
M146V | Alzheimer mutant presenilin-1 | Homo sapiens |
S276C | deletion of the PDZ domain of Omi/HtrA2 | Homo sapiens |
S306A | catalytically inactive Omi/HtrA2 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
35S-beta-casein + H2O | C-terminus of presenilin-1 interacts the PDZ domain of with Omi/HtrA2, increasing its activity | Homo sapiens | ? | - |
? | |
c-inhibitor of apoptosis protein1 + H2O | C-terminus of presenilin-1 interacts with the PDZ domain of Omi/HtrA2, increasing its activity | Homo sapiens | ? | - |
? | |
c-inhibitor of apoptosis protein2 + H2O | C-terminus of presenilin-1 interacts with the PDZ domain of Omi/HtrA2, increasing its activity | Homo sapiens | ? | - |
? | |
X-linked inhibitor of apoptosis protein + H2O | C-terminus of presenilin-1 interacts with the PDZ domain of Omi/HtrA2, increasing its activity | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Omi/HtrA2 | - |
Homo sapiens |
serine protease | - |
Homo sapiens |