Activating Compound | Comment | Organism | Structure |
---|---|---|---|
staurosporine | apoptotic stimulus to release 36-kDa protein fragment of HtrA2 and cytochrome c from the mitochondria to the cytosol | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression as GST fusions in Escherichia coli BL21 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S306A | endoproteolytic activity abolished | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by glutathione-Sepharose 4B beads | Homo sapiens |
Storage Stability | Organism |
---|---|
-70°C, Tris-HCl buffer, 20% glycerol, several months | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-casein + H2O | - |
Homo sapiens | ? | - |
? | |
X-linked inhibitor of apoptosis protein + H2O | autocatalytically processing of HtrA2 to the 36-kDa protein fragment, which is required for the cytochrome c-dependent caspase activation, promoting apoptotic cell death | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HtrA2/Omi | - |
Mus musculus |
HtrA2/Omi | - |
Homo sapiens |
HtrA2/Omi | - |
Rattus norvegicus |
HtrA2/Omi | - |
Sus scrofa |
HtrA2/Omi | - |
Bos taurus |
serine protease | - |
Mus musculus |
serine protease | - |
Homo sapiens |
serine protease | - |
Rattus norvegicus |
serine protease | - |
Sus scrofa |
serine protease | - |
Bos taurus |