Literature summary for 3.4.21.108 extracted from

Martins, L.M.; Iaccarino, I.; Tenev, T.; Gschmeissner, S.; Totty, N.F.; Lemoine, N.R.; Savopoulos, J.; Gray, C.W.; Creasy, C.L.; Dingwall, C.; Downward, J.
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif (2002), J. Biol. Chem., 277, 439-444.

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Protein Variants

Protein Variants	Comment	Organism
additional information	truncated mutant lacking the putative mitochondrial localization motif in the first 33 amino acid residues shows distribution throughout the cell with no obvious concentration in the mitochondria	Homo sapiens
S306A	localization is similar to wild-type	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	mitochondria also contain processed Omi which, following apoptotic insult, translocates to the cytosol	Homo sapiens	5739	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
35000	-	mass spectroscopy experiments	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	role in apoptosis, binds to XIAP-binding protein	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	first 133 amino acids are removed by autoproteolysis	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
293 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
beta-casein + H2O	-	Homo sapiens	?	-	?
additional information	role in apoptosis, binds to XIAP-binding protein	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
HtrA2/Omi	-	Homo sapiens
Omi	-	Homo sapiens

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Release 2023.1 (January 2023)