Literature summary for 3.4.21.107 extracted from

Sun, M.L.; Sun, L.M.; Wang, Y.Q.
Peptide selectivity between the PDZ domains of human pregnancy-related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen probes (2018), J. Mol. Recognit., 31, e2698 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
DSRIWWV	native peptide ligand, binds to the domain with a moderately high affinity (Kd 1.9 microM). the peptide selectivity is changed by 1.4fold, 3.8fold, 7.0fold, and 2.1fold upon fluorination, chlorination, bromination, and iodization of the Trp-1 indole, respectively	Homo sapiens
FGRWV	peptide ligand	Homo sapiens
WTMFWV	peptide ligand	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q92743	-	-

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Release 2023.1 (January 2023)