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Literature summary for 3.4.21.107 extracted from

  • Ochiai, N.; Nakachi, Y.; Yokoo, T.; Ichihara, T.; Eriksson, T.; Yonemoto, Y.; Kato, T.; Ogata, H.; Fujimoto, N.; Kobayashi, Y.; Udagawa, N.; Kaku, S.; Ueki, T.; Okazaki, Y.; Takahashi, N.; Suda, T.
    Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment (2019), Commun. Biol., 2, 86 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus Q9R118
-
-

Source Tissue

Source Tissue Comment Organism Textmining
osteoclast
-
 Mus musculus
-
RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
osteoprotegerin + H2O
-
 Mus musculus ?
-
 ?

General Information

General Information Comment Organism
physiological function HtrA1 is an osteoprotegerin-degrading enzyme. Inhibitory activity of osteoprotegerin on receptor activator of NF-kappaB ligand RANKL-induced osteoclastogenesis is suppressed by adding HtrA1 in RAW 264.7 cell cultures Mus musculus