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Literature summary for 3.4.21.107 extracted from

  • Patel, P.; De Boer, L.; Timms, P.; Huston, W.
    Evidence of a conserved role for Chlamydia HtrA in the replication phase of the chlamydial developmental cycle (2014), Microbes Infect., 16, 690-694.
    View publication on PubMed
Search for more literature for 3.4.21.107

Inhibitors

Inhibitors Comment Organism Structure
N-(tert-butoxycarbonyl)-L-valyl-N-[(1R)-1-(diphenoxyphosphoryl)-2-methylpropyl]prolinamide i.e. JO146. Inhibition during the replicative phase results in significant loss of viable infectious progeny Chlamydia pecorum
N-(tert-butoxycarbonyl)-L-valyl-N-[(1R)-1-(diphenoxyphosphoryl)-2-methylpropyl]prolinamide i.e. JO146. Inhibition during the replicative phase results in significant loss of viable infectious progeny Chlamydia suis
N-(tert-butoxycarbonyl)-L-valyl-N-[(1R)-1-(diphenoxyphosphoryl)-2-methylpropyl]prolinamide i.e. JO146. Inhibition during the replicative phase results in significant loss of viable infectious progeny Chlamydia trachomatis

Organism

Organism UniProt Comment Textmining
Chlamydia pecorum
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Chlamydia suis
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Chlamydia trachomatis
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General Information

General Information Comment Organism
physiological function Chlamydia trachomatis isolates with distinct replicative phase growth kinetics show significant loss of viable infectious progeny after HtrA is inhibited during the replicative phase Chlamydia trachomatis